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What is Circadian Health?

Health, Wellness, Longevity, and Quality of Life

The lifestyle choices you make today contribute to a cumulative health deficit that effect’s your body’s ability to manage chronic stress, consumption and metabolism of sugar, quality sleep, and chronic inflammation over time. In terms of your overall health, understanding how your lifestyle influences key aspects of stress, sleep, metabolism, and inflammation is priority #1 for change, but how do you know if you are on track?

It’s time to take a closer look at the “rhythm of your health”.

rhythm of biology

The Rhythm of a Healthy Lifestyle

Your physiology has natural rhythms, some are diurnal, circadian, and others ultradian. These rhythms work in sync to maintain balance and overall wellness. Picture your rhythm like the music at a concert. We hear music with a defined harmony produced because the sounds the instruments produce are aligned given a set rhythm. Now consider what’s produced when the components of the orchestra are reading different music, have different timing, or playing notes that are not in sync with the other sections. The difference in the product is striking.

Our bodies operate on a circadian rhythm, which determines when we should be awake, asleep, eating, relaxing, or active, and is guided by an internal master clock called the suprachiasmatic nucleus (SCN). This “body clock” coordinates critical physiological processes in our bodies, such as regulating blood pressure, heart rate, breathing, alertness, and hormone levels throughout the day. Healthy lifestyle choices—such as maintaining good sleep, diet, and exercise habits—help keep this rhythm in sync, promoting balance in our overall health. Health, longevity, and wellness are often associated with the proper alignment and coordination between these systems.

Environmental ques, such as the onset of offset of the daily dark-light cycle, often orchestrate the on and off switches for each of these critical processes. Unfortunately, our contemporary lifestyles are rarely in-sync with these natural rhythms. When our bodies respond too early or too late, or not at all to these natural environmental ques, our wellness becomes out of sync as well and our bodies suffer the consequences.

Key Hormones over a 24-HR Cycle

Long-term effects of Rhythmic Disruption

When your body’s natural rhythms fall out of sync due to consistently poor sleep, chronic stress, or unhealthy eating, widespread dysynchrony occurs in how your biology is regulated. This misalignment disrupts critical processes such as hormone production, digestion, immune response, and energy balance. Over time, these disruptions can contribute to a range of health concerns, including metabolic disorders, cardiovascular issues, impaired cognitive function, and weakened immune defenses. As the body struggles to adapt, it can lead to chronic fatigue, weight gain, mood disturbances, and an overall decline in well-being. As these disruptions accumulate, they may increase the risk of developing more serious health conditions, such as cardiovascular disease, diabetes, or cognitive disorders and impairments. These cumulative effects of rhythmic disruption highlight the importance of maintaining a healthy balance in sleep, stress, and nutrition to support long-term health and resilience.

Monitoring Your Body’s Natural Biorhythms to Control the Trajectory of Your Health

After more than 25 years of active engagement in the scientific community, we have targeted four pillars of a healthy lifestyle that are pivotal to overall health and wellness. Each pillar can be assessed using a minimally invasive technique self-administered in the convenience of your home. By enabling multiple samples to be collected at specific times across the day, you can now monitoring how your lifestyle impacts your overall health and wellness over time.

  • Stress – Elevated cortisol levels can signal prolonged stress, which contributes to poor immune function, weight gain, and mental fatigue. Regular cortisol testing allows you to pinpoint stress triggers and take control of stress management before it leads to serious health problems.
  • Sleep – Tracking melatonin helps you understand your natural sleep-wake cycle, ensuring you get restful, restorative sleep. Poor melatonin production is linked to insomnia and sleep disturbances, which in turn lead to fatigue, poor focus, and emotional instability. We can also help predict an optimal bedtime and evaluate if supplemental melatonin is in your system during the day.
  • Metabolism – Insulin testing reveals how efficiently your body handles glucose throughout the day. Early detection of insulin resistance helps prevent diabetes, obesity, and cardiovascular disease by enabling timely interventions in diet and lifestyle. Type II diabetes takes years of progressively worse insulin resistance to manifest and is completely reversible. Our insulin test can track your progress towards insulin sensitivity. Importantly, insulin regulation is recognized as an earlier indicator of pre-diabetes than glucose.
  • Inflammation – Chronic low levels of C-reactive protein (CRP) levels indicate persistent low-grade inflammation, which is linked to a wide range of conditions including heart disease, arthritis, and even cancer. Monitoring CRP helps you manage inflammation through diet, exercise, and stress reduction strategies.

Pioneers Driving the Science

For over 25 years, our team has pioneered the science of saliva-based testing. We have created the methods for sample collection, built the assays that have become standards for use in saliva measurements, and published more than 400 peer reviewed papers on applications of saliva testing ranging from pediatrics to gerontology. Our methodology is the gold standard and has been adopted and used in over 10,400 scientific studies. Now we are translating that research into a science-backed way to improve your life.

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saliva-sample-drop

Patterns and Trajectories

Learning how your life choices influence your physiology requires more than just a snapshot—it demands a deeper understanding of your body’s natural rhythms over time, which you can’t achieve through conventional testing methodologies, such as a blood draw at a lab, or a single sample time-point. That’s where a healthy lifestyle check comes in. It’s not about a once-a-year visit to your doctor or a once-in-a-lifetime biomarker panel; it’s about routinely capturing the full picture of your body’s daily patterns over time.

By monitoring the 4 pillars of health through representative biomarkers, we can provide precise, personalized insights into how your lifestyle is impacting your sleep, stress, and metabolism to focus on what matters most. This includes the opportunity to isolate and assess just one of these topics and monitoring how your choices influence change in that measurement. Then you can more easily focus on and implement what specific lifestyle changes provide the most impact on your health and wellness overall.

Detailed Health Insights in Every Drop

Saliva is the cornerstone of our methodology, because it’s the only biospecimen type that offers a unique way to understand your physiology without the hassle of invasive procedures or overnight lab stay. Here’s why saliva is ideal:

  1. Multi-time Point Measurements: To truly understand your biological rhythms, testing must happen throughout the day, or on multiple days and not just one sample, once a year. Our saliva-based assessments are designed for easy, repeating collections, ensuring that we capture these essential fluctuations in your biomarkers.
  2. Key Timing for Peak Insight: The key to understanding your body lies in assessing it during specific key moments in time—whether it’s your highest cortisol levels in the morning or melatonin at night. Our tests can be designed to ensures that we measure key biomarkers when they matters most.
  3. Convenience and Comfort: We’ve made the process as simple as possible. Collect your samples at home, either by yourself or with the help of family members. No need for invasive blood draws or repeated clinic visits—just a quick, easy, and minimally intrusive to your normal routine.

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SEMINAL PUBLICATIONS

  1. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. JAMA. 2007;298(14):1685-1687.
  2. Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep. 2017;9:151-161.
  3. Reaven GM. The metabolic syndrome: time to get off the fence? J Clin Endocrinol Metab. 2011;96(9):2593-2595.
  4. Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140(6):871-882.
  5. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80(1):40-52.
Contact: Salimetrics (USA)
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